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Best Weight Loss Pills in 2022 – Top 5 Diet Supplements for Your Weight Loss Journey

Nearly half of all people in the US have attempted or are currently trying a weight loss regimen.

Presented by Originated Media October 11, 2022

Nearly half of all people in the US have attempted or are currently trying a weight loss regimen. For many, the journey will be long and hard, but ultimately successful thanks to better diets and plenty of exercise. But healthier living alone may not be enough for everyone to get to their ideal body weight. 

That's where weight loss supplements come in. Weight loss pills are an excellent way to boost your metabolism, suppress your appetite, and give your body the extra energy it needs to make it through your diet and exercise regimen.

With the thousands of weight loss pills on the market, it can be incredibly challenging to know which ones are truly as safe and effective as they claim to be. That is why we've created this list of the best weight loss pills to help you on your journey to your dream body.

5 Best Weight Loss Pills

  1. PhenQ - Overall Best Weight Loss Pill 
  2. TrimTone - Best for Women
  3. Instant Knockout - Great for Athletes
  4. Zotrim - For Overeaters
  5. PhenGold - For Slow Metabolisms

Best Weight Loss Pills Reviewed

1. PhenQ - Overall Best Weight Loss Pill


  • Backed by scientific research
  • 5x better weight loss efforts
  • Natural ingredients
  • Free delivery


  • Limit of 5 bottles per household

About PhenQ

PhenQ is a powerful weight loss supplement backed by scientific research. It is 5x more effective than other weight loss pills on the market and contains natural ingredients that are safe for most people to take. In addition, the company manufactures its products in FDA-approved facilities using cGMP-certified practices.

The brand is always at the forefront of the latest scientific discoveries to ensure its products are as effective as possible. They also have a strong commitment to customer service, offering free delivery on all orders and a 60-day money-back guarantee. Customers can also enjoy comprehensive support on their weight loss journey with live support available to help with exercise, a healthy diet, and lifestyle tips that make it easier to stay on track.

How Does PhenQ Work?

PhenQ's natural weight loss ingredients work by stimulating thermogenesis. This process releases stored body fat so that it can be used for energy. The result is increased weight loss, more energy, and suppressed appetite.

The natural ingredients in PhenQ are all designed to support these goals, offering a comprehensive solution to lose weight that is safe and effective for most people. PhenQ's most essential ingredients to help meet weight loss goals include:

  • α-LACYS RESET® - A mix of amino acids, magnesium, and cysteine base, this patented formula is designed to help the body burn fat more effectively and efficiently
  • Capsimax Powder - A powerful blend of capsicum, piperine, caffeine, and niacin that stimulates thermogenesis to release stored fat so it can be used for energy
  • Nopal Cactus - A great source of fiber that helps to keep you feeling fuller for longer and helps to reduce cravings
  • Chromium Picolinate - An essential mineral that helps to regulate blood sugar levels, preventing cravings for sugary snacks
  • L-Carnitine Fumarate - An amino acid that helps the body convert body fat into energy, providing more power for workouts
  • Caffeine - A stimulant that helps to increase energy levels, making it easier to stick to your diet and exercise regimen for the best chances of losing weight

These ingredients combined into an easy-to-swallow tablet make PhenQ a comprehensive weight loss solution that is as convenient as it is effective. To date, these popular weight loss supplements have already helped nearly 200,000 people see the results they're looking for. PhenQ best weight loss pills are available in one, two, and three-month supplies with bonus free bottles available for larger purchases.

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2. TrimTone - Best Weight Loss Pill for Women


  • Specially formulated for women
  • One capsule per day
  • Scientifically proven natural ingredients
  • 24/7 thermogenesis stimulation


  • Gelatin capsules are not suitable for vegetarians or vegans

About TrimTone

TrimTone has been working since 1999 to create powerful and effective weight loss pills for women. All of their products are backed by scientific research and contain natural ingredients that have been proven to be safe and effective.

TrimTone's unique selling point is its 24/7 thermogenesis stimulation. This means the body constantly burns fat, even at rest. As a result, users can see more significant and long-lasting results with these popular weight loss supplements than with other weight loss pills on the market.

The brand offers free shipping and a 100-day money-back guarantee on all of its cGMP-manufactured weight loss supplements. The company also maintains a highly responsive live chat support so you can ask all the questions you need to make the best decision to achieve your weight loss objectives.

How Does TrimTone Work?

TrimTone's thermogenic fat burner uses natural ingredients that kick metabolism into high gear, boost energy, and suppress cravings to lose body weight. The brand uses natural ingredients specifically chosen to work with the unique biochemistry of women for the best results, with key ingredients that include:

  • Glucomannan - A natural fiber that absorbs water and creates a feeling of fullness, helping to reduce cravings.
  • Green Tea Extract - A natural source of caffeine and antioxidants that boosts energy levels and promotes faster metabolic rates to help lose weight.
  • Grains of Paradise - A natural root from the ginger family with outstanding thermogenic properties that help to promote fat burning.
  • Green Coffee Bean - A powerful antioxidant that helps to boost metabolism, promote thermogenesis and support weight loss.
  • Caffeine - Included to help promote lipolysis for the better breakdown of fat and to boost energy levels.

These ingredients' thermogenic properties mean that your body will continue to burn fat even when you're not actively working out or dieting, making it easier to maintain your weight loss results in the long term. Additionally, these supplements offer support without any adverse side effects often associated with weight loss pills, such as jitteriness or crashes.

TrimTone's thermogenic fat burner is suitable for adult women of all shapes and sizes. The company recommends taking one capsule daily with water, ideally 20-30 minutes before breakfast. Ordering a two month supply will get you a free bottle, and ordering a three months’ supply will get you two free bottles. 

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3. Instant Knockout - Great for Athletes


  • Vegan-friendly
  • Independently lab tested for quality
  • Promotes muscle retention
  • Vitamin-rich formula


  • Requires taking one capsule 4x per day

About Instant Knockout

Instant Knockout aims to help athletes, professional fighters, and those who want to trim the fat and to sculpt muscle reach their ideal body weight and shape. The product is made with natural ingredients that have thermogenic and fat-burning properties, as well as vitamins and minerals that help promote a healthy metabolism.

Instant Knockout's products are manufactured in FDA-inspected and GMP-certified facilities in the United Kingdom. In addition to detailed overviews of the ingredients and what makes the product so effective, the website also features a range of information discussing various topics related to fitness, nutrition, and losing weight.

How Does Instant Knockout Work?

This weight loss brand uses nearly a dozen natural ingredients that stimulate thermogenesis, help to burn fat and promote a healthy metabolism. The ingredients in Instant Knockout's thermogenic fat burner include:

  • Green Tea Extract - A natural source of caffeine and antioxidants that boost energy levels and promote faster metabolic rates.
  • Cayenne Pepper Seeds - A thermogenic spice that helps to promote the breakdown of fat cells to help you lose weight faster.
  • Glucomannan - A natural fiber that creates a feeling of fullness, helping to reduce cravings and support weight loss.
  • Black Pepper Extract - Helps the body to absorb the other ingredients more effectively.
  • L-Theanine - An amino acid that helps to promote relaxation without drowsiness for better rest leading to better focus and energy.
  • Vitamins - D3 included to support a healthy metabolism, B6 to help convert food into energy, and B12 for a wide range of functions, including red blood cell production for better muscle oxygenation.

With added natural sources of caffeine to ensure your body has the energy it needs to lose weight, particularly to lose belly fat, and see more muscle tone and definition, Instant Knockout is the ideal supplement for athletes or those that want to achieve a ripped physique.

Bottles can be purchased in 1-3 months supplies with better pricing and shipping options for larger orders. Capsules from Instant Knockout should be taken 4 times per day according to the instructions on the packaging.

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4. Zotrim - For Overeaters


  • 100% herbal formula
  • Highly effective appetite suppressant
  • Vegan-friendly
  • Medically reviewed


  • It doesn't contain thermogenic ingredients

About Zotrim

Zotrim takes a unique approach to weight loss pills by targeting the most common cause of weight gain - overeating. The product is made with a proprietary blend of herbs clinically shown to help control hunger cravings and reduce the urge to snack between meals.

Zotrim is also one of the few weight loss brands that have published clinical studies on their website to validate the claims made about the product. This information, combined with the very detailed FAQ section, makes Zotrim one of the most trustworthy brands in the industry when it comes to controlling weight gain through appetite suppression.

How Does Zotrim Work?

These weight loss pills use a proprietary blend of three herbs vital to curbing hunger cravings related to stress, sadness, or boredom. This means that users are less likely to snack on unhealthy foods or overeat at mealtimes - avoiding the most common cause of weight gain. The key herbal ingredients in Zotrim formula include:

  • Yerba Mate - A South American herb used for centuries to help control hunger and reduce cravings. The plan has also been shown to reduce the development of new fat cells, leading to long-term weight loss.
  • Guarana Seed (Extract) - A tropical fruit that is a natural source of caffeine. The added stimulant helps to boost energy levels, convert fat into energy, promote a healthy metabolism, and sustain healthy body weight.
  • Damiana Leaf - An herbal extract used in Central and South America for centuries to help control hunger. The ingredient is also thought to help improve mood and reduce stress levels, two common triggers for overeating.
  • Caffeine - Caffeine is included in Zotrim to help improve focus, increase energy levels, and reduce the urge to snack.

This unique blend of herbal, all-natural ingredients gives Zotrim its incredible appetite-suppressing power. By reducing the frequency you eat, Zotrim has created the perfect product for those who want to lose weight by eating less.

Because Zotrim is designed as an appetite suppressant, dosing varies from person to person. A 30-day supply is factored at 6 tablets per day before meals. In certain cases, when hunger cravings are particularly strong, some may find it necessary to take up to 9 tablets per day to see desired results.

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5. PhenGold - For Slow Metabolisms


  • Allergen-free
  • No side effects
  • Lab tested
  • Max strength formula


  • Higher price point than others on this list

About PhenGold

PhenGold takes safe and effective weight loss seriously with a powerfully effective weight loss pill designed to target the three main areas of losing weight - thermogenesis, metabolism, and appetite suppression. By combining a blend of over a dozen of the best ingredients to support every aspect of weight loss, PhenGold has become one of the most popular and effective diet pills on the market.

As part of its commitment to transparency, safety, and quality, PhenGold provides tons of information on its website supporting claims, including a full list of ingredients, dosages, and clinical studies. PhenGold is also GMP certified and made in the USA in an FDA-registered facility, ensuring that customers are getting a product to lose weight that is safe to consume and meets the highest quality standards.

How Does PhenGold Work?

The key to PhenGold's success lies in its multi-action approach. By targeting the three most important areas of weight loss, PhenGold is able to provide users with a well-rounded supplement that helps them lose weight in a safe and healthy way. Key ingredients in PhenGold include:

  • L-Tyrosine - An amino acid that has been shown to help improve thermogenesis, the process by which your body burns fat for energy.
  • Green Tea Extract - A powerful antioxidant that helps to boost metabolism and promote fat loss.
  • Cayenne Pepper - A spice that helps to increase thermogenesis and support a healthy appetite.
  • Rhodiola Rosea - An herb that helps to reduce stress and promote a healthy mood.
  • DMAE - A compound that helps to improve focus and cognitive function.
  • Green Coffee - A natural source of caffeine that helps to boost energy levels and promote fat loss.
  • Vitamin blend - D3, B6, & B12 are included to help suppress appetite, boost energy levels, and promote a healthy metabolism.

PhenGold's powerful ingredients work together with added natural sources of caffeine to create a supplement designed to help you lose weight quickly and safely. Additionally, the all-natural capsules are free from common allergens such as dairy, gluten, and soy, making them an excellent choice for those with dietary restrictions.

These best weight loss supplements come in 30-day supplies (90 capsules) and can be purchased in one to three month quantities that all come with free shipping. PhenGold is most effective when taking three capsules about 15-20 minutes before breakfast.

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What We Considered to Choose Our Best Weight Loss Pills

Our research into what makes the best weight loss pills began by looking at customer testimonials and brand reputation. These two factors are often the best predictor of a product's effectiveness. From there, we took an in-depth look at many other factors critical to getting a successful weight loss pill, including:

  • Formulation: We only considered weight loss supplements that used all-natural ingredients and avoided those with potentially harmful side effects.
  • Transparency: Brands that are upfront about their ingredients, dosages, and research used to support their claims were the only ones that we considered.
  • Safety: Only brands that manufacture their products in FDA-registered facilities and avoid using risky or untested ingredients made our list.

By combining these factors with our team's personal experience with each weight loss supplement, we were able to create this comprehensive list of the best weight loss pills.

What to Look for in Quality Pills to Lose Weight

Nothing is more frustrating than spending money on a product that doesn't work. This is especially true with weight loss supplements since failure to work often makes people less motivated to stay on track with their diet and exercise goals. To avoid this frustration, there are certain factors you should look for when choosing best weight loss pills


The ingredients are key to any effective weight loss supplement. Be sure to choose products formulated with nothing but all-natural ingredients, such as:

  • Green tea extract
  • Cayenne pepper
  • Green coffee bean extract
  • Yerba Mate
  • Guarana seed extract
  • Vitamins B6 & B12
  • Magnesium

These ingredients are clinically proven to provide the most weight loss benefit without the potentially dangerous side effects often seen with synthetic ingredients or prescription weight loss pills.

Furthermore, the ingredients in the formula you choose should also work towards your specific weight loss goals. For example, if you want to suppress your appetite, you will want to find a product that contains ingredients like green tea extract or guarana seed extract. 

On the other hand, if you are looking for an energy boost to help power through your weight loss workouts, then you might want to find a product that contains caffeine or other natural energy boosters. And if you want to boost thermogenesis to help lose belly fat or trim other trouble spots, you might want to find a product that contains ingredients like green coffee bean extract or cayenne pepper.

Concentration of Ingredients

Even with the best all-natural formula, weight loss pills still need a concentrated amount of each ingredient to help lose or avoid excess body fat. Typically, products with a higher concentration of its key ingredients will be more effective. Effective amounts for common weight loss supplement ingredients include:

  • Green tea extract: 250-500mg
  • Cayenne pepper: 100-200mg
  • Green coffee bean extract: no less than 100mg
  • Amino Acids (L-tyrosine, L-theanine) - no less than 150mg

These amounts will, of course, vary from formula to formula depending on the specific ingredients used and the number of pills that need to be taken during the day. But, in general, you should look for products that use amounts at or above these levels to ensure maximum effectiveness.

Frequency of Use

Though the frequency of use will be a matter of personal preference, it is still an essential quality for choosing the best weight loss pills for your needs. Products with extensive usage instructions or that need to be taken multiple times per day can be hard to keep up with - causing many people to simply give up and quit taking them.

While once-per-day pills may seem like the most convenient option, they might not be enough to protect against food cravings throughout the day or give you the energy you need for your weight loss workouts.

For these reasons, it is essential to consider your personal weight loss goals and find a product that has a frequency of use you can easily incorporate into your lifestyle. This way, you can ensure a higher likelihood of success in meeting your desired goals.

Manufacturing Practices

All natural ingredients, amounts of those ingredients, and dosing schedules are only as good as the manufacturing practices used to create the products. This is because even the best-formulated weight loss pill can be rendered useless if it is not properly manufactured.

Only purchase supplements made in an FDA-registered, Good Manufacturing Practices (GMP) certified facility to ensure you get a product that works safely and as intended. This ensures that the product has been made according to the highest quality standards and is safe for human consumption.

Additionally, look for products that have been third-party tested by an independent organization for microbial, heavy metals, and other contaminants. 

What Do Weight Loss Supplements Do?

Weight loss supplements are designed to promote four factors critical to losing weight:

  • Suppressing appetite
  • Increasing energy levels
  • Promoting thermogenesis
  • Improving metabolism

Appetite suppression is important because it can help to control the number of calories you consume each day. If you find it difficult to stick to a calorie-restricted diet, then an appetite suppressant can help by making it easier to control your hunger.

Increasing energy levels is also vital because it can help you stay motivated during exercise and make healthy diet choices. And, if you are working out more frequently or for longer periods, then you will need more energy to fuel your workouts and avoid feeling fatigued.

Thermogenesis is the process of heat production in the body that helps lose or avoid excess body fat. By taking a weight loss supplement formulated with thermogenic ingredients, you'll have the best chances of maximizing thermogenesis and promoting weight loss.

Improving metabolism is the key to sustainable weight loss because it helps your body to burn calories more effectively. If you have a slow metabolism, then you may find it difficult to lose weight or keep it off in the long term. But, by taking a supplement that boosts your metabolism, you can help your body more effectively burn body fat and calories.

How To Use Weight Loss Pills

Every manufacturer has different instructions for using weight loss pills safely and with the best results. Following the specific directions for each product is essential to ensure you are taking it correctly.

Weight loss supplements come in single and multiple dose options. Single-dose options are typically taken once daily, while multiple-dose products might require you to take 4-6 pills daily.

When taking any weight loss pill, be sure to drink plenty of water throughout the day. This helps to prevent dehydration, which can occur when taking some thermogenic supplements.

Be aware that weight loss pills are not as effective if taken on their own without any additional changes to your lifestyle. Yes, these supplements will help suppress appetite and stimulate your body's fat-burning potential, but they are not magic pills that will cause you to lose weight without any effort.

To maximize results, be sure to pair weight loss pills with a healthy diet and regular exercise. This combination of lifestyle changes and all-natural weight loss pills will help you lose weight safely and effectively.

When is the Best Time to Take Weight Loss Supplements?

Most weight loss pills have detailed instructions as to the best time to take the weight loss supplements. Typically, thermogenesis supplements will need to be taken with food - especially if the goal is to stimulate the process for a significant loss of weight. This is because taking the pills with food will help to minimize the risk of side effects like nausea or an upset stomach.

Exceptions to this rule are when you use formulas designed to suppress appetite rather than stimulate fat burning. Often in the case of those already on a strict diet plan or those shaping up for a sporting event, taking an appetite suppressing weight loss supplement (often referred to as diet pills) as needed up to a certain amount of times a day is acceptable. Be sure to read the instructions for each product to ensure you are taking them as directed.

Additionally, manufacturers will recommend that you take their products at certain times of the day for optimal results. This is usually in the morning or before meals but can also be during specific workout intervals, as is the case with some pre-workout thermogenic supplements.

How Long Does it Take Weight Loss Pills to Work?

Weight loss supplements are usually incorporated into a diet and exercise routine to boost the speed at which results can be seen and felt. Many of the brands on this list provide testimonials from customers who saw results in as little as 2-4 weeks, but most say the best results happen within 2-3 months of taking the pills. These results, however, are not always typical and will vary depending on factors such as:

  • Current body fat percentage: How much body weight you need to lose will largely determine how quickly you will see results. Those with large stores of body fat may lose weight at a different rate than those already at a healthy weight but are looking to tone up.
  • Exercise intensity and frequency: Exercise is vital to any weight loss journey, and those who exercise more frequently and with greater intensity will usually see results more quickly.
  • Dietary changes: Making healthier dietary choices is essential to sustainable weight loss. Eating more whole foods and fewer processed foods will help to improve overall health for better processing of ingredients in your best weight loss pills.

Speak with a fitness or medical professional before starting any program to lose weight to help you determine what results you can realistically expect and the best way to achieve them. They will also be able to monitor your progress and perhaps help with prescription weight loss drugs if over-the-counter natural supplement options aren’t working. Professionals can also help you to move away from supplements into more traditional methods like diet and exercise once you have reached your ideal weight.

Do Pills to Help Lose Body Weight Have Any Side Effects?

For many years, taking prescription weight loss drugs had risky side effects like addiction, high blood pressure, and heart attacks. But, with the development of all-natural weight loss supplements, the adverse side effects of prescription weight loss pills are now a thing of the past.

Natural weight loss pills are specially formulated to be side effect-free, allowing users with different allergies, sensitivities, and health conditions to use them safely. To ensure the safest and most beneficial results when taking supplements to lose weight, be sure to:

  • Speak with your doctor when taking other medications. Certain medical conditions might make it unsafe to take a weight loss pill. For example, those with high blood pressure, heart conditions, or diabetes may find that some ingredients, such as caffeine, can further complicate their health.
  • Do not exceed the recommended dose. Doses for weight loss supplements are created for a reason. These instructions help keep healthy levels of the ingredients in your system while preventing any adverse effects from overconsumption.
  • Choose formulas with all-natural ingredients. Natural ingredients in these pills are formulated to be gentle and easy for your body to process, resulting in fewer side effects for users. When taking the best weight loss pills made with all-natural ingredients, you can rest assured that you are not exposing yourself to any of the synthetic ingredients known to cause severe or potentially even fatal health concerns.
  • Pay attention to any changes in your body. If you experience any adverse effects after taking a supplement to lose weight, discontinue use immediately and speak with your doctor. While some effects, such as a slight headache or upset stomach, are common and usually go away on their own, more severe effects like chest pain, breathing difficulties, or fainting should be addressed by a medical professional right away.

Knowing how to avoid the risk of any side effects will guarantee that your experience with weight loss pills is safe and enjoyable.

Frequently Asked Questions

  1. Will taking a weight loss pill make me stay awake?

Ingredients like caffeine are commonly included in weight loss pills but not at levels that should cause jitteriness or sleeplessness. If you are sensitive to caffeine, consider taking a supplement that uses natural herbs rather than caffeine as its primary weight loss ingredient.

  1. Do I need to diet and exercise while taking weight loss pills?

While these supplements can help improve metabolism and suppress appetite to lose weight, the best and most sustainable results will always come from making dietary and lifestyle changes. A healthy diet and regular exercise should always be a part of any weight loss plan, with or without pills.

  1. Can I take weight loss pills while breastfeeding?

New mothers wanting to lose weight after having a baby should talk to their healthcare providers before considering any supplement, as some ingredients may not be recommended while breastfeeding.

  1. Do weight loss pills contain allergens?

Weight loss formulas vary from company to company, and some may contain or be manufactured in the same place as common allergens such as gluten, soy, or dairy. However, manufacturers of these supplements make these allergens clearly marked on their product labels. If you have any concerns about a weight loss supplement and allergens, be sure to check the ingredients list or contact the supplement company directly for more information.

  1. Are weight loss pills habit-forming?

No, natural weight loss pills are not habit-forming. These natural supplements contain ingredients that work synergistically with the body to avoid creating dependence or addiction. However, a weight loss pill containing synthetic stimulants may be habit-forming, which is why natural supplements are always recommended.

Reach Your Weight Goals Safely and Effectively

Meeting your weight goals with the help of a natural weight loss supplement is possible with the right product. Natural weight loss pills give you the support you need to reach your body weight goals without any risks associated with taking synthetic weight loss formulas. 

By choosing any of the best weight loss pills on this list, you can guarantee a safe and effective experience with a supplement that helps you look amazing and feel even better.