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Best Nitric Oxide Supplements – Top 5 NO2 Boosters for Muscle Building & ED

Muscles need oxygen and nutrients for peak energy and performance to be delivered quickly and efficiently.

Presented by Originated Media November 29, 2022

Muscles need oxygen and nutrients for peak energy and performance to be delivered quickly and efficiently. Unfortunately, as we age, our bodies become less efficient at delivering these essential nutrients - leading to fatigue, muscle deficiencies, and a general decline in performance.

But fortunately, there's a solution - nitric oxide supplements.

Naturally formulated to help improve blood flow and delivery of oxygen and nutrients to muscles, the best nitric oxide supplements can help to improve physical performance, cognitive functions, endurance, muscle mass, and strength.

Regardless of where you want to see improvements, the best nitric oxide supplements can help - and we've got the perfect list of products to get you started. 

5 Best Nitric Oxide Supplements

1. CrazyBulk - Best Nitric Oxide Supplements

2. Onnit - Best Fast-Acting Formula

3. VigRX - Best for Mobility & Physical Performance

4. Bulk Supplements - Best for Long-Term Use

5. Health Products For You - Best for Boosting Endurance

Detailed Reviews of the Best Nitric Oxide Boosters

1. CrazyBulk - Best Nitric Oxide Supplements


  • Boosts recovery time

  • Significantly improves stamina

  • 100% natural & safe ingredients

  • Free worldwide shipping


  • None

CrazyBulk Overview

At the heart of CrazyBulk's philosophy is the belief that everyone has the right to achieve their fitness goals, regardless of age, gender, or experience. And they live up to this belief by offering a range of high-quality, natural supplements designed to help people reach their fitness goals - quickly, safely, and effectively.

With products created by a team of in-house nutritionists, used by world-class athletes, and made using only the finest natural ingredients, CrazyBulk is a name that has become synonymous with quality and results.

CrazyBulk Best Nitric Oxide Supplements

Taking no shortcuts in the formulation process, CrazyBulk's nitric oxide supplement product has been designed to boost nitric oxide levels, improving blood flow and oxygen delivery to muscles and leading to increased stamina, endurance, and strength.

Made from only two natural ingredients - calcium and L-arginine - CrazyBulk's nitric oxide supplement is entirely safe, effective, and legal. And because it's free from artificial colors, flavors, or sweeteners, they're also gentle on the stomach and easy to take.

The calcium in the formula works to improve calcium absorption and utilization, while the L-arginine helps to increase nitric oxide production. Combined, these two ingredients work to create a powerful supplement that can help you reach your fitness goals - faster.

Capsules are sold in a 60ct bottle with a serving size of two capsules daily. All purchases come with a 14-day money-back guarantee, free shipping worldwide, and no prescription is required.

Why We Like CrazyBulk

Checking all of the boxes for quality, safety, and effectiveness, CrazyBulk is our pick for best nitric oxide supplements for a reason. Formulated using only the finest natural ingredients, manufactured in FDA-approved facilities, and backed by a team of world-class athletes - CrazyBulk is a name you can trust.

Learn more at CrazyBulk

2. Onnit - Best Fast-Acting Formula


  • Keto, Paleo, and vegan friendly

  • Contains no nuts, soy, or gluten

  • Antioxidant-rich formula

  • Clinically proven ingredients


  • High price point for free shipping

Onnit Overview

Physical performance, endurance, and stamina are just a few areas that Onnit's line of dietary supplements can help to support. Formulated using clinically proven ingredients, sourced from the finest natural sources and made in FDA-approved facilities - Onnit offers a range of high-quality supplements that can help you reach your fitness goals.

With generous return policies, detailed fitness resources and access to an online community of other health-conscious individuals with every purchase, Onnit is more than just a supplement company - they're a resource for living a healthier, happier life.

Onnit Best Nitric Oxide Supplements

Supporting physical and mental endurance for workouts, home life and everything in between - Onnit's best nitric oxide supplements are powdered and designed to help improve blood flow and oxygen delivery to muscles. As a result, users have reported incredible results when it comes to increased stamina, strength, and energy levels.

The berry-flavored powder supplement is made using four natural ingredients - L-citrulline, L-arginine, beetroot extract, and Careflow® mango powder. The first two ingredients are considered an amino acid that supports nitric oxide production, while the beetroot extract and Careflow® mango powder are rich in antioxidants and help to fight free radicals and support healthy eNOS activity for improved cardiovascular function.

What really makes this supplement stand out is its fast-acting formula. Unlike many other nitric oxide supplements that can take 30-60 minutes to kick in, Onnit's formula is designed to boost nitric oxide production within minutes - giving you the energy and stamina you need when you need it most.

Why We Like Onnit

While other nitric oxide supplements can take time to kick in, Onnit's formula is designed to start boosting nitric oxide production fast. Combined with its clean ingredient list and easy-to-use powder format, we think this is one of the best nitric oxide supplements on the market.

Learn more at Onnit

3. VigRX - Best for Mobility & Physical Performance


  • Clinically researched formula

  • Maximum strength ingredients

  • Facilitates better blood pressure

  • Boosts immune support


  • Packaging may be too large for travel

VigRX Overview

Focused on providing all-natural solutions for improved physical health and performance, VigRX has been a trusted name in the wellness industry for years. The company invests a lot of time, money, and energy into formulating unique solutions backed by science and clinically proven to work.

VigRX's line of dietary supplements is protected by a 67-day money-back guarantee and comes with free domestic shipping in the USA. With 24/7 customer support and a 100% secure payment system, VigRX is a name you can trust.

VigRX Best Nitric Oxide Supplements

Designed to boost nitric oxide levels and support healthy blood pressure levels, VigRX's nitric oxide supplement is formulated using clinically researched ingredients designed to maximize results. By improving blood flow and oxygen delivery to muscles, the supplement can help to improve physical performance, endurance, and stamina.

The maximum strength formula contains potent doses of L-citrulline and L-arginine. These two amino acids offer a range of health benefits but are especially effective in supporting nitric oxide production for improved blood circulation.

In addition to its physical performance benefits, the supplement is also designed to support cognitive function, mental clarity, and immunity. These three aspects are all interrelated to physical health; by supporting one, you can indirectly support the others.

Capsules are available in a range of package options in one to six-month supplies. Each bottle contains 90 capsules designed to be taken thrice daily with meals before any physical activity.

Why We Like VigRX

VigRX is a company that is dedicated to providing unique all-natural solutions that are backed by science. We like that their nitric oxide supplement is formulated using clinically researched ingredients and comes with a 67-day money-back guarantee.

Learn more at VigRX

4. BulkSupplements - Best for Long-Term Use


  • 133 servings per pouch

  • No dairy, gluten, wheat, soy

  • Supports brain health

  • Manufactured using cGMP standards


  • Free shipping is not available to all 50 states

BulkSupplements Overview

Long being a staple in the fitness community, BulkSupplements is a company that has only recently begun to receive mainstream attention. The company manufactures a wide range of dietary supplements in powder, capsule, and tablet form.

Using cGMP manufacturing practices in ISO-certified labs, BulkSupplements is able to provide high-quality supplements at an affordable price. The company offers free shipping on all domestic orders over $59 and has a 30-day money-back satisfaction guarantee.

BulkSupplements Best Nitric Oxide Supplements

Using a natural derivative of L-arginine in the form of agmatine sulfate, BulkSupplements' best nitric oxide booster is designed to offer a range of health benefits. Why agmatine sulfate? This ingredient is known to be more stable and longer-lasting in the body than L-arginine, making it a more effective choice for those looking for improved blood circulation for better physical performance and cognitive function.

With agmatine sulfate being the only ingredient in the supplement, BulkSupplements has created a product that is also suitable for any dietary lifestyle or need. Free from sugar, gluten, wheat, soy, dairy, and artificial ingredients, the supplement is also vegan and halal-friendly.

One pouch of powder contains 133 servings, making it one of the most cost-effective options on our list to boost nitric oxide production. In addition, the powder is tasteless and can be easily mixed into water or your favorite beverage.

Why We Like BulkSupplements

We like that BulkSupplements provides a product that lasts up to four times longer than other nitric oxide supplements on this list. Additionally, we like that the company uses only one ingredient in their supplement to boost nitric oxide levels, which is clinically researched and designed to improve blood circulation and cognitive function.

Learn more at BulkSupplements

5. Health Products For You - Best for Boosting Endurance


  • All-natural herbal formula

  • Boosted with vitamins and minerals

  • Increases energy

  • Helps lower blood pressure


  • No bulk buy discounts

Health Products For You Overview

Already helping over a million people reach their health and wellness goals, Health Products For You has been a trusted name in the industry since 2002. The company provides a wide range of health products, including mobility aids, fitness equipment, and dietary supplements.

The wellness brand makes finding the right products easy with a user-friendly website that provides clear product descriptions and customer reviews. Health Products For You also offers first-order discounts and has a 30-day return policy.

Health Products For You Best Nitric Oxide Supplements

The company’s best nitric oxide supplement is designed to be a natural alternative for those looking to improve their cardiovascular health. Composed of all-natural herbal ingredients such as grape and berry extracts, the supplement is designed to increase blood flow and improve circulation.

The supplement is also enhanced with vitamins and minerals such as vitamin C, calcium, and theobromine. These ingredients provide additional health benefits and also help to improve the absorption of the capsules for a potent nitric oxide production boost when you need it most.

The best part about this nitric oxide booster from Health Products For You is its natural stimulant properties. For those who prefer to get their physical exercise in at night or after a long day at the office, the added energy from the formula can help you power through your workout for powerful results.

Why We Like Health Products For You

We like that the company uses an all-natural herbal formula in its nitric oxide supplement. Additionally, we appreciate that the supplement is enhanced with vitamins and minerals for additional health benefits. Finally, we like that the capsules are easy to take and provide a powerful energy boost to support late/evening workouts.

Learn more at Health Products For You

What Went Into Making This Best Nitric Oxide Supplement List?

With hundreds and hundreds of brands claiming to have the best nitric oxide supplements on the market, it’s understandably hard to know what makes a product worth your time and money. To help you find the best nitric oxide boosters for your needs, we evaluated hundreds of brands and products based on the following criteria:

  • Effectiveness: We only included nitric oxide supplementation products that have been clinically shown to be effective at boosting nitric oxide production in the body.

  • Safety: All of the products on our list are composed of natural ingredients deemed safe for human consumption by the FDA.

  • Transparency: We only included brands that provide clear and accurate information about their nitric oxide supplementation products and manufacturing processes.

With these criteria as a base, we dove further into brands that made the cut examining customer reviews, certifications, and company reputation to narrow our list further. Finally, we compared our experiences with the products to its claims of boosting nitric oxide production - allowing us to create this ultimate list of the best nitric oxide boosters.

What is Nitric Oxide?

A free radical that can dilate blood vessels, nitric oxide (NO) is a gas that naturally occurs in the body, playing an essential role in cardiovascular, immune, mental, and physical health.

The majority of the nitric oxide in the body is produced in the endothelium - the layer of cells that line the blood vessels. Nitric oxide is made when an amino acid called L-arginine is converted into L-citrulline by an enzyme called nitric oxide synthase (eNOS).

Once produced, nitric oxide enters the smooth muscle cells lining the blood vessels and signals the cells to relax. This dilation of the blood vessels helps to improve circulation and lower blood pressure.

Additionally, nitric oxide is a key player in cognitive function and is involved in memory formation and learning. This is a direct result of nitric oxide's ability to stimulate the release of neurotransmitters in the brain.

Finally, nitric oxide is also involved in exercise and physical performance. With mobility, endurance, and energy all relying on optimal, sustained circulation, nitric oxide production is essential for peak physical performance.

Who Should Take Nitric Oxide Supplements?

Many people think nitric oxide supplements are just for athletes or bodybuilders. That's only partially accurate, however. While the amino acid supplement can be helpful for those looking to improve their physical performance, it also has several other benefits that make it ideal for a wide range of people.

For example, as we age our bodies naturally produce nitric oxide less and less. Unfortunately, this decline can contribute to many age-related health concerns, including decreased cognitive function, reduced immune support, and cardiovascular disease. So those considered "elderly" may want to consider taking nitric oxide supplements to help keep their bodies functioning optimally.

Additionally, those with chronic health conditions like diabetes or hypertension may also benefit from taking a nitric oxide supplement. This is because these conditions are often characterized by impaired circulation - which can be improved by boosting nitric oxide production.

People working in intense or physically demanding jobs are also prime candidates for benefiting from the best nitric oxide supplements. With boosted energy and endurance levels, hardworking men and women can easily power through their days.

Finally, anyone looking to improve their physical performance - whether for athletic purposes or to look better - may want to consider taking a nitric oxide supplement. With many of these products containing additional ingredients that work towards these goals, it's the perfect way to help you reach your fitness objectives without having to take multiple different supplements.

How Do You Know If Your Nitric Oxide Levels Are Low?

You won't have to look hard to understand if your nitric oxide levels are low. The symptoms are apparent, and the condition often leads to long-term damage. Some of the common symptoms of low nitric oxide levels include:

  • Erectile dysfunction

  • High blood pressure

  • Atherosclerotic plaque buildup in arteries (hardening)

  • Diabetes or insulin resistance

  • Chronic inflammation throughout the body

  • Fatigue or low energy levels

  • Muscle weakness or cramping

  • Slow wound healing

  • Poor cognitive function or memory loss

Additionally, if you are a regular smoker, eat over processed foods, or don't exercise, you are likely not producing enough nitric oxide - even if you aren't noticing the common symptoms.

Those unsure whether their wellness conditions result from low nitric oxide levels or other causes should consult a physician. A blood test checking amino acid levels can give a more accurate picture of whether low nitric acid is the cause.

What are the Benefits of a Nitric Oxide Supplement?

While some foods we eat provide the amino acid and enzyme compounds needed for healthy nitric oxide production, many people don't get enough of these nutrients from diet alone. This is where a high-quality nitric oxide supplement can help. 

Improved blood circulation

This is the most well-known benefit of taking a nitric oxide supplement. By dilating blood vessels and improving circulation, nitric oxide aids in the transport of oxygen and nutrients to the cells and organs - resulting in lower blood pressure, improved heart health, and increased physical performance.

Improved cognitive function

Ongoing research shows that by stimulating the release of neurotransmitters in the brain, nitric oxide can improve cognitive function, memory formation, and learning. This helps to reduce the chances of developing dementia or other age-related cognitive issues.

Reduced inflammation

Chronic inflammation is linked to a variety of severe health conditions, including heart disease, arthritis, and diabetes. Nitric oxide has natural anti-inflammatory properties that help to reduce chronic inflammation throughout the body, improving overall health and well-being.

Improved wound healing

By increasing blood flow and reducing inflammation, the best nitric oxide supplements can speed up the healing process for wounds and injuries. This is especially beneficial for those with low nitric oxide levels AND diabetes or other conditions that make wound healing more difficult. It is also great for fitness enthusiasts looking for a quick recovery after a workout.

A more robust immune system

Nitric oxide plays a vital role in immunity, helping fight infection and disease. This is due to nitric oxide's ability to kill bacteria and viruses while also stimulating the production of other important immune cells. As a result, taking nitric oxide supplements can help to improve overall immunity.

Boosted energy and endurance

By improving blood circulation and delivering oxygen and nutrients to the cells, the best nitric oxide supplements provide a natural energy boost. Higher nitric oxide levels can help fight fatigue, making it easier to get through the day. Additionally, by reducing oxidative stress and muscle damage, nitric oxide can improve physical endurance, making it easier to stay (or get) active.

How Much Nitric Oxide Should I Take?

It is always best to follow the use instructions printed on the packaging to ensure you are taking the correct (and appropriate) dose of amino acid nitric oxide supplements. Many products that boost nitric oxide levels are designed to be taken in specific doses for maximum results, so using more or less than the recommended amount can result in less-than-optimal results.

Typically, capsule formulas can be taken one to three times per day, depending on the concentration of the active ingredients. For example, a product with a lower L-arginine content may require multiple doses per day to achieve the desired effects. In contrast, a product with a higher concentration can be taken less frequently.

Powder formulas are generally mixed with water or juice and taken once or twice daily, depending on the concentration of active ingredients. Accurate dosing of powders can be tricky, so following package instructions will be vital in getting the most out of a powdered supplement.

Can You Overdose On Nitric Oxide?

Fortunately, nitric oxide is a gas quickly eliminated from the body, and there is no danger of accumulating toxic levels. But just as you can be deficient in nitric oxide levels, it is possible to have too much in your body. High nitric oxide levels are caused by many factors, including:

  • Diet: A diet rich in nitrate-containing foods can lead to elevated nitric oxide levels. This is why it is essential to speak with a doctor or registered dietitian before taking any nitric oxide-boosting supplements, especially if you have a history of hypertension.

  • Nitric oxide supplementation: Taking nitric oxide supplements in excess can lead to a nitric oxide overdose. While not lethal, it can have disorienting effects on coordination, balance, and blood pressure.

  • Medical conditions: Some medical conditions can cause the body to produce too much nitric oxide. These include sepsis, a potentially life-threatening condition caused by infection, and pulmonary hypertension, high blood pressure in the arteries of the lungs. 

Remember, it is always important to be aware of the potential for nitric oxide overdose and to speak with a doctor before taking any supplements to boost physical and mental performance.

When is the Best Time to Take a Nitric Oxide Supplement?

The time of day best for taking nitric oxide boosters varies based on the type of product being used, desired benefits, and other health factors. Knowing when to take your nitric oxide supplement can help you get the most out of them and improve your overall health.

Nitric Oxide Capsules

The best nitric oxide capsule formulas are usually taken one to three times a day. In some cases, users may take all capsules at once in the morning for a powerful boost of energy and benefits that last all day. Others may do the same in the evening to help support late-night workouts or boost energy for evening activities.

However, those seeking more targeted results find that spacing out doses to support specific goals throughout the day and night is most effective. For example, if you're looking to improve exercise performance, taking a dose before your workout can help deliver nutrients and oxygen to your muscles when they need it most. And then another dose in the evening to support muscle recovery as you sleep.

When you take nitric oxide capsules, remember two things: take them with food and do so at least 30 mins before or after the physical process you want to support. This way, you give the nutrients time to be properly absorbed into your system and you don't risk a digestive upset.

Nitric Oxide Powder

Powdered formulas are generally taken once or twice daily, depending on the concentration of active ingredients. In most cases, it is best to take powdered supplements in the morning so that you can enjoy the benefits throughout the day. However, some people prefer to take their nitric oxide powder at night or after daily workouts to help muscle recovery, revitalize energy levels, or boost focus for the evening ahead.

When taking powdered supplements, always mix them with water or juice as directed on the package. Because beverages bypass the digestive process, they are absorbed more quickly into the bloodstream taking nitric oxide powders no less than 15 minutes before or after physical activity is advised.

Do Nitric Oxide Supplements Have Any Side Effects?

Even when made from all-natural, lab-tested ingredients, all supplements have the potential to cause side effects, especially when taken in large doses or without food. While the best nitric oxide supplements are made using practices that ensure their safety, quality, and effectiveness, it is still possible to experience minor side effects, including but not limited to:

  • Upset stomach: A result of taking nitric oxide doses on an empty stomach or without food. To avoid this, always take your supplements with a meal or snack.

  • Nausea: Increasing nitric oxide levels too quickly by taking high doses or taking them on an empty stomach can cause nausea. If this occurs, lower your dose or take your supplement with food.

  • Dizziness and headache: As blood flow increases, so does blood pressure. In some cases, this results in dizziness or headache. If you experience these side effects, drink plenty of fluids and lie down until they pass.

  • Muscle cramps: While many people take nitric oxide supplements to relieve muscle pain and cramping, taking them in high doses can actually cause these symptoms. If you experience muscle cramps, lower your dose or take a break from supplementing for a few days.

These minor side effects usually dissipate when using the proper dosage of a high-quality supplement and are nothing to be concerned about. However, if you experience more severe side effects such as chest pain, shortness of breath, or an irregular heartbeat, stop taking the supplement immediately and consult a doctor.


1. Are nitric oxide supplements safe for women to use?

Yes, nitric oxide supplements are perfectly safe for women to use. In fact, many women find that these supplements offer many benefits, including improved exercise performance, reduced recovery time, and increased energy levels.

2. Is a nitric oxide supplement the same as steroids?

No, nitric oxide supplements are not the same as steroids. Steroids are hormones (some of which are illegal) that can be injected or taken orally to increase muscle mass, strength, and size. On the other hand, nitric oxide supplements are legal dietary supplements that support optimal blood flow and oxygen delivery to muscles.

3. How long does it take to see results after starting a nitric oxide supplement?

Most people begin to notice the benefits of nitric oxide boosters within a few weeks of taking them. However, it may take up to two months of regular supplementation to experience the full effects.

4. Do I need to cycle off nitric oxide boosters?

No, there is no need to cycle off a nitric oxide supplement. The natural amino acids, vitamins, and herbs in many nitric oxide supplements provide long-lasting benefits with no need for cycling. However, in some cases, you may want to take a break from the supplements to adjust for any new or achieved fitness goals.

5. Do nitric oxide boosters contain banned substances?

No, the best nitric oxide supplements do not contain any banned substances. Many nitric oxide supplements are made using all-natural ingredients that are safe for everyone to use. However, it is always best to read third-party lab reports for each product to ensure it is safe (and legal) to take for your specific needs.

Nitric Oxide Supplementation for Better Performance, Recovery, & Energy Levels

The best nitric oxide booster is a safe and effective way to improve exercise performance, recovery time, and energy levels. These all-natural supplements are legal, natural, and easy to take, making them an ideal choice for athletes and fitness enthusiasts of all levels.

Not sure which supplement will be best to boost nitric oxide levels in your body? Consider purchasing any of the best nitric oxide supplements we recommend on this list, and get on your way to better fitness and health today!